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{"sheet":"Inputs & Results","index":0,"n_rows":60,"n_cols":14,"rows_kept":60,"cut":false,"hidden":false,"merged":[[15,1,15,3],[16,1,16,3],[3,1,3,13],[6,1,6,13],[7,1,7,13],[8,1,8,13],[9,1,9,13],[10,1,10,13],[11,1,11,13],[12,1,12,13],[13,1,13,13]]}
[]
[null,"Model Information"]
[null,"DESCRIPTION"]
[null,"Drug Therapy Added to Lifestyle Intervention for Prediabetes"]
[]
[null,"STRATEGIES"]
[null,"Lifestyle Tx - Standard of care"]
[null,"Base case of only lifestyle intervention"]
[null,"Metformin Tx"]
[null,"Generic Metformin"]
[null,"Tirzepatide Tx"]
[null,"GLP-1 receptor agonist Tirzepatide"]
[null,"Semaglutide Tx"]
[null,"GLP-1 receptor agonist Semaglutide"]
[]
[null,"Green cells are editable"]
[null,"Gray cells - no impact on calculation"]
[null,"INPUTS",null,null,null,"MODEL RESULTS"]
[null,"Description","Value","Reference in TreeAge",null,"WTP:",23500]
[null,"Parameter Variables",null,null,null,"Strategy","Cost","Eff","Payoff 3 - \nLife expectancy"]
[null,"Quality of Life in state NGT by Neumann et al. (2014) in \"Health-related quality of life for pre-diabetic states and type 2 diabetes mellitus: a cross-sectional study in Västerbotten Sweden\" PMID: 25342083.",0.76800000000000002,"vQoLNGT",null,"Metformin Tx",{"$f":"'2. Strategy Calcs'!K130","v":118078.44470615756},{"$f":"'2. Strategy Calcs'!M130","v":22.158641560113239},{"$f":"'2. Strategy Calcs'!O130","v":29.064691009166914}]
[null,"Quality of life in state IFG by Neumann et al. (2014) in \"Health-related quality of life for pre-diabetic states and type 2 diabetes mellitus: a cross-sectional study in Västerbotten Sweden\" PMID: 25342083.",0.75900000000000001,"vQoLIFG",null,"Lifestyle Tx - Standard of care",{"$f":"'1. Strategy Calcs'!K130","v":122169.87934993705},{"$f":"'1. Strategy Calcs'!M130","v":22.137236140234972},{"$f":"'1. Strategy Calcs'!O130","v":29.045424427097604}]
[null,"Quality of life in state IGT by Neumann et al. (2014) in \"Health-related quality of life for pre-diabetic states and type 2 diabetes mellitus: a cross-sectional study in Västerbotten Sweden\" PMID: 25342083.",0.746,"vQoLIGT",null,"Tirzepatide Tx",{"$f":"'3. Strategy Calcs'!K130","v":138800.798304186},{"$f":"'3. Strategy Calcs'!M130","v":22.354037105770619},{"$f":"'3. Strategy Calcs'!O130","v":29.260892829540335}]
[null,"Quality of life in state combined by Neumann et al. (2014) in \"Health-related quality of life for pre-diabetic states and type 2 diabetes mellitus: a cross-sectional study in Västerbotten Sweden\" PMID: 25342083.",0.745,"vQoLCombined",null,"Semaglutide Tx",{"$f":"'4. Strategy Calcs'!K130","v":158810.96637440854},{"$f":"'4. Strategy Calcs'!M130","v":22.342477446390802},{"$f":"'4. Strategy Calcs'!O130","v":29.250183404379079}]
[null,"Quality of life in state T2D by Neumann et al. (2014) in \"Health-related quality of life for pre-diabetic states and type 2 diabetes mellitus: a cross-sectional study in Västerbotten Sweden\" PMID: 25342083.",0.73799999999999999,"vQoLT2D"]
[null,"Quality of life in state Death.",0,"vQoLDeath"]
[null,"Annual cost in state NGT, based on Neumann et al. (2011) from Liebl et al. (2007) in \"Kosten in der Früh- und Spätphase des Diabetes mellitus\" PMID: 22099547.",3380.85,"cNGT",null,"Category","Strategy","Cost","Incr. Cost","Eff","Incr. Eff","ICER","NMB","CE"]
[null,"Annual cost in state T2D, based on Neumann et al. (2011) from Liebl et al. (2007) in \"Kosten in der Früh- und Spätphase des Diabetes mellitus\" PMID: 22099547.",8295.7099999999991,"cT2D",null,"Undominated","Metformin Tx",118078.44470615756,null,22.158641560113239,null,null,{"$f":"J28*WTP - H28","v":402649.63195650355},5328.7763325124224]
[null,"Annual cost in state IGT, based on assumption, that they estimate to 46% of T2D costs by Neumann (2011) Estimating the cost-effectiveness of lifestyle intervention programmes to prevent diabetes based on an example from Germany: Markov modelling",3816.03,"cIGT",null,"Undominated","Tirzepatide Tx",138800.798304186,20722.353598028436,22.354037105770619,0.19539554565738015,106053.35719558531,{"$f":"J29*WTP - H29","v":386519.07368142356},6209.2049703341972]
[null,"Annual cost in state IFG, based on assumption, that they estimate to 46% of T2D costs by Neumann (2011) Estimating the cost-effectiveness of lifestyle intervention programmes to prevent diabetes based on an example from Germany: Markov modelling",3816.03,"cIFG",null,"Abs. dominated","Lifestyle Tx - Standard of care",122169.87934993705,null,22.137236140234972,null,null,{"$f":"J30*WTP - H30","v":398055.16994558484},5518.7503343242697]
[null,"Annual cost in state Combined, based on assumption, that they estimate to 46% of T2D costs (estimation by Palmer et al) by Neumann (2011) Estimating the cost-effectiveness of lifestyle intervention programmes to prevent diabetes based on an example from Germany: Markov modelling",3816.03,"cCombined",null,"Abs. dominated","Semaglutide Tx",158810.96637440854,null,22.342477446390802,null,null,{"$f":"J31*WTP - H31","v":366237.25361577526},7108.028496636698]
[null,"Transition prob from Combined to IFG. 10 year probability by Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",1.2569E-2,"pCombinedToIFG"]
[null,"Transition prob from Combined to IGT. 10 year probability by Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",8.7519999999999994E-3,"pCombinedToIGT"]
[null,"Transition prob from IFG to Combined. 10 year probability by Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",6.3010000000000002E-3,"pIFGToCombined"]
[null,"Transition prob from IFG to IGT. 10 year probability by Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",4.4190000000000002E-3,"pIFGToIGT"]
[null,"Transition prob from IGT to Combined. 10 year probability by Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",8.2039999999999995E-3,"pIGTToCombined"]
[null,"Transition prob from IGT to IFG. 10 year probability by Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",6.3177999999999998E-2,"pIGTToIFG"]
[null,"Transition prob from NGT to T2D. Based on Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",3.1389999999999999E-3,"pNGTToT2D"]
[null,"Riskfactor age. Age in years.",50,"rAge"]
[null,"Riskfactor blood pressure. 0 = SYS < 140 & DIA < 90; 1 = SYS > 140 & DIA > 90",0,"rBloodPressure"]
[null,"Riskfactor BMI. 1 = <25, 2 = >25 &<30, 3 = >30",1,"rBMI"]
[null,"Riskfactor education. 1 = >12 years education, 2 = 10-12 years, 3 = <10 years",2,"rEducation"]
[null,"Riskfactor five a day. 1 = yes, 2 = no",2,"rFiveADay"]
[null,"Riskfactor gender. 1 = male, 2 = female",1,"rGender"]
[null,"Risk factor heredity. 1 = no heredity, 2 = yes",1,"rHeredity"]
[null,"Riskfactor marital status. 1 = married, 2 = single",1,"rMaritalStatus"]
[null,"Risk factor physical activity. 0 = activ, 1 = decently active, 2 = sitting",1,"rPhysicalActivity"]
[null,"Riskfactor smoking. 1 = never, 2 = in the past , 3 = currently",1,"rSmoking"]
[null,"Riskfactor snus. 1 = no use, 2 = <4 doses/week , 3 = > 4 doses/week",1,"rSnus"]
[null,"Riskfactor triglyceride. 0 = <1,69mmol/l , 1 = >1,69mmol/l",0,"rTriglyceride"]
[null,"Annual cost of Tirzepatide intervention with 15mg application dosag eper week. Taken from shop-Apotheke.de in August 2024.",4146,"cTirzepatideTx"]
[null,"Annual cost of Semaglutide intervention with 2,4mg application dosage per week. Taken from shop-Apotheke.de in August 2024.",6615.6,"cSemaglutideTx"]
[null,"Annual cost of Lifestyle intervention adapted from Neumann (2011) Estimating the cost-effectiveness of lifestyle intervention programmes to prevent diabetes based on an example from Germany: Markov modelling",376.95,"cLifestyleTx"]
[null,"Annual cost of Metformin intervention with 2x 850mg per day. Taken from shop-Apotheke.de in August 2024.",69.92,"cMetforminTx"]
[null,"T2D remission probability under Tirzepatide taken from D. Vasdeki (2022) in \"Remission as an Emerging Therapeutic Target in Type 2 Diabetes in the Era of New Glucose-Lowering Agents: Benefits, Challenges, and Treatment Approaches\".",0.13878548344,"vRemissionTirzepatide"]
[null,"T2D remission probability under Semaglutide taken from D. Vasdeki (2022) in \"Remission as an Emerging Therapeutic Target in Type 2 Diabetes in the Era of New Glucose-Lowering Agents: Benefits, Challenges, and Treatment Approaches\".",0.12271089484,"vRemissionSemaglutide"]
[null,"Transition prob from T2D to NGT. 10 year probability by Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",2.3252999999999999E-2,"pT2DToNGTDefault"]
[null,"Risk factor perceived health. 1 = very good, pretty good , 2 = somewhat good, pretty bad, bad",1,"rPerceivedHealth"]
[null,"Parameter distributions"]
[null,"",8.5,"distProfiles"]

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[null,"Strategy",1,"Lifestyle Tx - Standard of care"]
[null,"States","All"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"NGT - State 1.1",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"T2D - State 1.2",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IFG - State 1.3",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IGT - State 1.4",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Combined - State 1.5",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Death - State 1.6"]
[null,null,null,"Cohort State Proportions",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Cohort %",null,null,null,null,null,null,null,"Payoff 1 - Total direct treatment costs",null,null,"Payoff 2 - Quality adjusted life-years",null,null,"Payoff 3 - Life expectancy",null,null,"Cohort %",null,null,null,null,null,null,null,"Payoff 1 - Total direct treatment costs",null,null,"Payoff 2 - Quality adjusted life-years",null,null,"Payoff 3 - Life expectancy",null,null,"Cohort %",null,null,null,null,null,null,null,"Payoff 1 - Total direct treatment costs",null,null,"Payoff 2 - Quality adjusted life-years",null,null,"Payoff 3 - Life expectancy",null,null,"Cohort %",null,null,null,null,null,null,null,"Payoff 1 - Total direct treatment costs",null,null,"Payoff 2 - Quality adjusted life-years",null,null,"Payoff 3 - Life expectancy",null,null,"Cohort %",null,null,null,null,null,null,null,"Payoff 1 - Total direct treatment costs",null,null,"Payoff 2 - Quality adjusted life-years",null,null,"Payoff 3 - Life expectancy",null,null,"Cohort %",null,"Payoff 2 - Quality adjusted life-years"]
[null,"Cycle",null,"NGT","T2D","IFG","IGT","Combined","Death","Payoff 1 - Total direct treatment costs",null,"Payoff 2 - Quality adjusted life-years",null,"Payoff 3 - Life expectancy",null,null,"Checksum of Cohort %",null,"1.1\n State","1.1.1\n Transition","1.1.1.1\n Transition","1.1.1.2\n Transition","1.1.1.3\n Transition","1.1.1.4\n Transition","1.1.1.5\n Transition","1.1.2\n Transition","1.1\nState before WCC","1.1\nState after WCC","State/Trans","1.1\nState before WCC","1.1\nState after WCC","State/Trans","1.1\nState before WCC","1.1\nState after WCC","State/Trans","1.2\n State","1.2.1\n Transition","1.2.1.1\n Transition","1.2.1.2\n Transition","1.2.1.3\n Transition","1.2.1.4\n Transition","1.2.1.5\n Transition","1.2.2\n Transition","1.2\nState before WCC","1.2\nState after WCC","State/Trans","1.2\nState before WCC","1.2\nState after WCC","State/Trans","1.2\nState before WCC","1.2\nState after WCC","State/Trans","1.3\n State","1.3.1\n Transition","1.3.1.1\n Transition","1.3.1.2\n Transition","1.3.1.3\n Transition","1.3.1.4\n Transition","1.3.1.5\n Transition","1.3.2\n Transition","1.3\nState before WCC","1.3\nState after WCC","State/Trans","1.3\nState before WCC","1.3\nState after WCC","State/Trans","1.3\nState before WCC","1.3\nState after WCC","State/Trans","1.4\n State","1.4.1\n Transition","1.4.1.1\n Transition","1.4.1.2\n Transition","1.4.1.3\n Transition","1.4.1.4\n Transition","1.4.1.5\n Transition","1.4.2\n Transition","1.4\nState before WCC","1.4\nState after WCC","State/Trans","1.4\nState before WCC","1.4\nState after WCC","State/Trans","1.4\nState before WCC","1.4\nState after WCC","State/Trans","1.5\n State","1.5.1\n Transition","1.5.1.1\n Transition","1.5.1.2\n Transition","1.5.1.3\n Transition","1.5.1.4\n Transition","1.5.1.5\n Transition","1.5.2\n Transition","1.5\nState before WCC","1.5\nState after WCC","State/Trans","1.5\nState before WCC","1.5\nState after WCC","State/Trans","1.5\nState before WCC","1.5\nState after WCC","State/Trans","1.6\n State","1.6.1\n Transition","1.6\nState before WCC","1.6\nState after WCC","State/Trans",null,"HazardRatioIGTToDeath","HazardRatioT2DToDeath","pCombinedToDeath","pIFGToDeath","pIFGToNGT","pIGTToDeath","pIGTToNGT","pNGTToCombined","pNGTToDeath","pNGTToIFG","pNGTToIGT","pT2DToDeath"]
[null,null,null,null,null,null,null,null,null,"WCC Disc","Cum Disc","WCC Disc","Cum Disc","WCC Disc","Cum Disc",null,null,null,"NGT","Alive","Stay in NGT","IFG","To Combined","T2D","IGT","Death","NGT","NGT","State Total","NGT","NGT","State Total","NGT","NGT","State Total","T2D","Alive","Stay in T2D","IFG","To Combined","NGT","IGT","Death","T2D","T2D","State Total","T2D","T2D","State Total","T2D","T2D","State Total","IFG","Alive","Stay in IFG","To Combined","T2D","NGT","IGT","Death","IFG","IFG","State Total","IFG","IFG","State Total","IFG","IFG","State Total","IGT","Alive","Stay in IGT","IFG","To Combined","NGT","T2D","Death","IGT","IGT","State Total","IGT","IGT","State Total","IGT","IGT","State Total","Combined","Alive","Stay in Combined","IFG","T2D","NGT","IGT","Death","Combined","Combined","State Total","Combined","Combined","State Total","Combined","Combined","State Total","Death","Stay in Death","Death","Death","State Total"]
[]
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[]
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[null,"Strategy",3,"Tirzepatide Tx"]
[null,"States","All"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"NGT - State 3.1",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"T2D - State 3.2",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IFG - State 3.3",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IGT - State 3.4",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Combined - State 3.5",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Death - State 3.6"]
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[null,null,null,null,null,null,null,null,null,"WCC Disc","Cum Disc","WCC Disc","Cum Disc","WCC Disc","Cum Disc",null,null,null,"NGT","Alive","Stay in NGT","IFG","To Combined","T2D","IGT","Death","NGT","NGT","State Total","NGT","NGT","State Total","NGT","NGT","State Total","T2D","Alive","Stay in T2D","IFG","To Combined","NGT","IGT","Death","T2D","T2D","State Total","T2D","T2D","State Total","T2D","T2D","State Total","IFG","Alive","Stay in IFG","To Combined","T2D","NGT","IGT","Death","IFG","IFG","State Total","IFG","IFG","State Total","IFG","IFG","State Total","IGT","Alive","Stay in IGT","IFG","To Combined","NGT","T2D","Death","IGT","IGT","State Total","IGT","IGT","State Total","IGT","IGT","State Total","Combined","Alive","Stay in Combined","IFG","T2D","NGT","IGT","Death","Combined","Combined","State Total","Combined","Combined","State Total","Combined","Combined","State Total","Death","Stay in Death","Death","Death","State Total"]
[]
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{"sheet":"4. Strategy Calcs","index":4,"n_rows":130,"n_cols":121,"rows_kept":130,"cut":false,"hidden":false,"merged":[[2,86,2,102],[3,103,3,104],[3,105,3,107],[2,103,2,107],[4,16,5,16],[2,52,2,68],[3,69,3,76],[3,77,3,79],[3,80,3,82],[3,83,3,85],[2,69,2,85],[2,18,2,34],[3,35,3,42],[3,43,3,45],[3,46,3,48],[3,49,3,51],[2,35,2,51],[4,119,5,119],[4,120,5,120],[3,18,3,25],[3,26,3,28],[3,29,3,31],[3,32,3,34],[3,52,3,59],[3,60,3,62],[3,63,3,65],[3,66,3,68],[3,86,3,93],[3,94,3,96],[3,97,3,99],[3,100,3,102],[4,114,5,114],[4,115,5,115],[4,116,5,116],[4,117,5,117],[4,118,5,118],[4,109,5,109],[4,110,5,110],[4,111,5,111],[4,112,5,112],[4,113,5,113],[4,7,5,7],[4,8,5,8],[4,9,4,10],[4,11,4,12],[4,13,4,14],[0,3,0,6],[3,3,3,5],[4,1,5,1],[4,3,5,3],[4,4,5,4],[4,5,5,5],[4,6,5,6]]}
[null,"Strategy",4,"Semaglutide Tx"]
[null,"States","All"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"NGT - State 4.1",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"T2D - State 4.2",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IFG - State 4.3",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"IGT - State 4.4",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Combined - State 4.5",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Death - State 4.6"]
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[null,null,null,null,null,null,null,null,null,"WCC Disc","Cum Disc","WCC Disc","Cum Disc","WCC Disc","Cum Disc",null,null,null,"NGT","Alive","Stay in NGT","IFG","To Combined","T2D","IGT","Death","NGT","NGT","State Total","NGT","NGT","State Total","NGT","NGT","State Total","T2D","Alive","Stay in T2D","IFG","To Combined","NGT","IGT","Death","T2D","T2D","State Total","T2D","T2D","State Total","T2D","T2D","State Total","IFG","Alive","Stay in IFG","To Combined","T2D","NGT","IGT","Death","IFG","IFG","State Total","IFG","IFG","State Total","IFG","IFG","State Total","IGT","Alive","Stay in IGT","IFG","To Combined","NGT","T2D","Death","IGT","IGT","State Total","IGT","IGT","State Total","IGT","IGT","State Total","Combined","Alive","Stay in Combined","IFG","T2D","NGT","IGT","Death","Combined","Combined","State Total","Combined","Combined","State Total","Combined","Combined","State Total","Death","Stay in Death","Death","Death","State Total"]
[]
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["State Transition Diagram of Strategy:","Lifestyle Tx - Standard of care",null,null,null,null,null,null,null,"Tree Diagram"]
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["State Transition Diagram of Strategy:","Metformin Tx"]
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[]
[]
[]
["Green cells are editable"]
["Changing this may require manual changes to Excel formulas"]

{"sheet":"Original Data & Results","index":7,"n_rows":46,"n_cols":10,"rows_kept":46,"cut":false,"hidden":false,"merged":[[3,6,3,9],[10,6,10,9],[17,6,17,9]]}
[]
[null,"Original Data from TreeAge Pro Model"]
[]
[null,"INPUTS",null,null,null,null,"CURRENT MODEL RESULTS"]
[null,"Description","Value","Reference in TreeAge",null,null,{"$f":"'Inputs & Results'!F20","v":"Strategy"},{"$f":"'Inputs & Results'!G20","v":"Cost"},{"$f":"'Inputs & Results'!H20","v":"Eff"},{"$f":"'Inputs & Results'!I20","v":"Payoff 3 - \nLife expectancy"}]
[null,"Parameter Variables",null,null,null,null,{"$f":"'Inputs & Results'!F21","v":"Metformin Tx"},{"$f":"'Inputs & Results'!G21","v":118078.44470615756},{"$f":"'Inputs & Results'!H21","v":22.158641560113239},{"$f":"'Inputs & Results'!I21","v":29.064691009166914}]
[null,"Quality of Life in state NGT by Neumann et al. (2014) in \"Health-related quality of life for pre-diabetic states and type 2 diabetes mellitus: a cross-sectional study in Västerbotten Sweden\" PMID: 25342083.",0.76800000000000002,"vQoLNGT",null,null,{"$f":"'Inputs & Results'!F22","v":"Lifestyle Tx - Standard of care"},{"$f":"'Inputs & Results'!G22","v":122169.87934993705},{"$f":"'Inputs & Results'!H22","v":22.137236140234972},{"$f":"'Inputs & Results'!I22","v":29.045424427097604}]
[null,"Quality of life in state IFG by Neumann et al. (2014) in \"Health-related quality of life for pre-diabetic states and type 2 diabetes mellitus: a cross-sectional study in Västerbotten Sweden\" PMID: 25342083.",0.75900000000000001,"vQoLIFG",null,null,{"$f":"'Inputs & Results'!F23","v":"Tirzepatide Tx"},{"$f":"'Inputs & Results'!G23","v":138800.798304186},{"$f":"'Inputs & Results'!H23","v":22.354037105770619},{"$f":"'Inputs & Results'!I23","v":29.260892829540335}]
[null,"Quality of life in state IGT by Neumann et al. (2014) in \"Health-related quality of life for pre-diabetic states and type 2 diabetes mellitus: a cross-sectional study in Västerbotten Sweden\" PMID: 25342083.",0.746,"vQoLIGT",null,null,{"$f":"'Inputs & Results'!F24","v":"Semaglutide Tx"},{"$f":"'Inputs & Results'!G24","v":158810.96637440854},{"$f":"'Inputs & Results'!H24","v":22.342477446390802},{"$f":"'Inputs & Results'!I24","v":29.250183404379079}]
[null,"Quality of life in state combined by Neumann et al. (2014) in \"Health-related quality of life for pre-diabetic states and type 2 diabetes mellitus: a cross-sectional study in Västerbotten Sweden\" PMID: 25342083.",0.745,"vQoLCombined"]
[null,"Quality of life in state T2D by Neumann et al. (2014) in \"Health-related quality of life for pre-diabetic states and type 2 diabetes mellitus: a cross-sectional study in Västerbotten Sweden\" PMID: 25342083.",0.73799999999999999,"vQoLT2D",null,null,"ORIGINAL MODEL RESULTS FROM EXCEL"]
[null,"Quality of life in state Death.",0,"vQoLDeath",null,null,"Strategy","Cost","Eff","Payoff 3 - \nLife expectancy"]
[null,"Annual cost in state NGT, based on Neumann et al. (2011) from Liebl et al. (2007) in \"Kosten in der Früh- und Spätphase des Diabetes mellitus\" PMID: 22099547.",3380.85,"cNGT",null,null,"Metformin Tx",118078.44470615756,22.158641560113239,29.064691009166914]
[null,"Annual cost in state T2D, based on Neumann et al. (2011) from Liebl et al. (2007) in \"Kosten in der Früh- und Spätphase des Diabetes mellitus\" PMID: 22099547.",8295.7099999999991,"cT2D",null,null,"Lifestyle Tx - Standard of care",122169.87934993705,22.137236140234972,29.045424427097604]
[null,"Annual cost in state IGT, based on assumption, that they estimate to 46% of T2D costs by Neumann (2011) Estimating the cost-effectiveness of lifestyle intervention programmes to prevent diabetes based on an example from Germany: Markov modelling",3816.03,"cIGT",null,null,"Tirzepatide Tx",138800.798304186,22.354037105770619,29.260892829540335]
[null,"Annual cost in state IFG, based on assumption, that they estimate to 46% of T2D costs by Neumann (2011) Estimating the cost-effectiveness of lifestyle intervention programmes to prevent diabetes based on an example from Germany: Markov modelling",3816.03,"cIFG",null,null,"Semaglutide Tx",158810.96637440854,22.342477446390802,29.250183404379079]
[null,"Annual cost in state Combined, based on assumption, that they estimate to 46% of T2D costs (estimation by Palmer et al) by Neumann (2011) Estimating the cost-effectiveness of lifestyle intervention programmes to prevent diabetes based on an example from Germany: Markov modelling",3816.03,"cCombined"]
[null,"Transition prob from Combined to IFG. 10 year probability by Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",1.2569E-2,"pCombinedToIFG",null,null,"ORIGINAL MODEL RESULTS FROM TREEAGE PRO"]
[null,"Transition prob from Combined to IGT. 10 year probability by Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",8.7519999999999994E-3,"pCombinedToIGT",null,null,"Strategy","Cost","Eff","Payoff 3 - \nLife expectancy"]
[null,"Transition prob from IFG to Combined. 10 year probability by Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",6.3010000000000002E-3,"pIFGToCombined",null,null,"Metformin Tx",118078.44470611877,22.158641560107714,29.064691009159546]
[null,"Transition prob from IFG to IGT. 10 year probability by Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",4.4190000000000002E-3,"pIFGToIGT",null,null,"Lifestyle Tx - Standard of care",122169.87934989503,22.137236140229341,29.045424427090044]
[null,"Transition prob from IGT to Combined. 10 year probability by Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",8.2039999999999995E-3,"pIGTToCombined",null,null,"Tirzepatide Tx",138800.79830413271,22.354037105765425,29.260892829533383]
[null,"Transition prob from IGT to IFG. 10 year probability by Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",6.3177999999999998E-2,"pIGTToIFG",null,null,"Semaglutide Tx",158810.96637433249,22.342477446384962,29.250183404371281]
[null,"Transition prob from NGT to T2D. Based on Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",3.1389999999999999E-3,"pNGTToT2D"]
[null,"Riskfactor age. Age in years.",50,"rAge"]
[null,"Riskfactor blood pressure. 0 = SYS < 140 & DIA < 90; 1 = SYS > 140 & DIA > 90",0,"rBloodPressure"]
[null,"Riskfactor BMI. 1 = <25, 2 = >25 &<30, 3 = >30",1,"rBMI"]
[null,"Riskfactor education. 1 = >12 years education, 2 = 10-12 years, 3 = <10 years",2,"rEducation"]
[null,"Riskfactor five a day. 1 = yes, 2 = no",2,"rFiveADay"]
[null,"Riskfactor gender. 1 = male, 2 = female",1,"rGender"]
[null,"Risk factor heredity. 1 = no heredity, 2 = yes",1,"rHeredity"]
[null,"Riskfactor marital status. 1 = married, 2 = single",1,"rMaritalStatus"]
[null,"Risk factor physical activity. 0 = activ, 1 = decently active, 2 = sitting",1,"rPhysicalActivity"]
[null,"Riskfactor smoking. 1 = never, 2 = in the past , 3 = currently",1,"rSmoking"]
[null,"Riskfactor snus. 1 = no use, 2 = <4 doses/week , 3 = > 4 doses/week",1,"rSnus"]
[null,"Riskfactor triglyceride. 0 = <1,69mmol/l , 1 = >1,69mmol/l",0,"rTriglyceride"]
[null,"Annual cost of Tirzepatide intervention with 15mg application dosag eper week. Taken from shop-Apotheke.de in August 2024.",4146,"cTirzepatideTx"]
[null,"Annual cost of Semaglutide intervention with 2,4mg application dosage per week. Taken from shop-Apotheke.de in August 2024.",6615.6,"cSemaglutideTx"]
[null,"Annual cost of Lifestyle intervention adapted from Neumann (2011) Estimating the cost-effectiveness of lifestyle intervention programmes to prevent diabetes based on an example from Germany: Markov modelling",376.95,"cLifestyleTx"]
[null,"Annual cost of Metformin intervention with 2x 850mg per day. Taken from shop-Apotheke.de in August 2024.",69.92,"cMetforminTx"]
[null,"T2D remission probability under Tirzepatide taken from D. Vasdeki (2022) in \"Remission as an Emerging Therapeutic Target in Type 2 Diabetes in the Era of New Glucose-Lowering Agents: Benefits, Challenges, and Treatment Approaches\".",0.13878548344,"vRemissionTirzepatide"]
[null,"T2D remission probability under Semaglutide taken from D. Vasdeki (2022) in \"Remission as an Emerging Therapeutic Target in Type 2 Diabetes in the Era of New Glucose-Lowering Agents: Benefits, Challenges, and Treatment Approaches\".",0.12271089484,"vRemissionSemaglutide"]
[null,"Transition prob from T2D to NGT. 10 year probability by Neumann et al. (2013) in \"Risk equations for the development of worsened glucose status and type 2 diabetes mellitus in a Swedish intervention program\" PMID: 24502249.",2.3252999999999999E-2,"pT2DToNGTDefault"]
[null,"Risk factor perceived health. 1 = very good, pretty good , 2 = somewhat good, pretty bad, bad",1,"rPerceivedHealth"]
[null,"Parameter distributions"]
[null,"",8.5,"distProfiles"]

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["Global Discounting"]
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["Cycle",null,"Payoff 1 - \nTotal direct treatment costs","Payoff 1 - \nTotal direct treatment costs\n(Transition)","Payoff 2 - \nQuality adjusted life-years","Payoff 2 - \nQuality adjusted life-years\n(Transition)","Payoff 3 - \nLife expectancy","Payoff 3 - \nLife expectancy\n(Transition)"]
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{"sheet":"TP Internal Formulas","index":9,"n_rows":100,"n_cols":9,"rows_kept":100,"cut":false,"hidden":true,"merged":[[98,0,98,2],[99,0,99,2],[2,0,2,10],[3,0,3,10],[47,0,47,10],[86,0,86,10],[94,0,94,10]]}
["EXTRAS"]
[]
["This worksheet includes elements from the TreeAge Pro model that are not actively used in the exported Excel model."]
["They are included here for reference only."]
[]
["TreeAge Pro Variable Sensitivity Analysis Range"]
[]
["Name","Low","High"]
["vQoLNGT",0.1,0.1]
["vQoLIFG",0.1,0.1]
["vQoLIGT",0.1,0.1]
["vQoLCombined",0.1,0.1]
["vQoLT2D",0.1,0.1]
["vQoLDeath",0,0]
["cNGT",0.1,0.1]
["cT2D",0.1,0.1]
["cIGT",0.1,0.1]
["cIFG",0.1,0.1]
["cCombined",0.1,0.1]
["pCombinedToIFG",0.1,0.1]
["pCombinedToIGT",0.1,0.1]
["pIFGToCombined",0.1,0.1]
["pIFGToIGT",0.1,0.1]
["pIGTToCombined",0.1,0.1]
["pIGTToIFG",0.1,0.1]
["pNGTToT2D",0.1,0.1]
["rAge",40,60]
["rBloodPressure",0,1]
["rBMI",1,3]
["rEducation",1,3]
["rFiveADay",1,2]
["rGender",1,2]
["rHeredity",1,2]
["rMaritalStatus",1,2]
["rPhysicalActivity",0,2]
["rSmoking",1,3]
["rSnus",1,3]
["rTriglyceride",0,1]
["cTirzepatideTx",0.1,0.1]
["cSemaglutideTx",0.1,0.1]
["cLifestyleTx",0.1,0.1]
["cMetforminTx",0.1,0.1]
["vRemissionTirzepatide",0.1,0.1]
["vRemissionSemaglutide",0.1,0.1]
["pT2DToNGTDefault",0.1,0.1]
["rPerceivedHealth",0,1]
[]
["Sensitivity analysis ranges are used in TreeAge Pro, but not in the converted Excel model."]
[]
[]
["TreeAge Pro Variable Formulas"]
[]
["Name","Value"]
["HazardRatioIGTToDeath","if(_stage < 50;-0,0002*(rAge+_stage)^2+0,0019*(rAge+_stage)+2,3148; 1,14)"]
["HazardRatioT2DToDeath","if(_stage < 50;-0,0002*(rAge+_stage)^2+0,0019*(rAge+_stage)+2,4097; 1,19)"]
["pCombinedToDeath","if(\n\trGender = 1; \n\tHazardRatioIGTToDeath * tMortalityWithoutDiabetes[rAge + _stage; 1]; \n\tHazardRatioIGTToDeath * tMortalityWithoutDiabetes[rAge + _stage; 2]\n)"]
["pIFGToDeath","if(\r\n\trGender = 1; \r\n\tHazardRatioIGTToDeath * tMortalityWithoutDiabetes[rAge + _stage; 1]; \r\n\tHazardRatioIGTToDeath * tMortalityWithoutDiabetes[rAge + _stage; 2]\r\n)"]
["pIFGToNGT","(1-exp(-(-ln(1-(1/(1+exp((-1)*(2,84-0,43*rHeredity -0,02* (rAge + _stage) - 0,23 * rEducation - 0,25 * rBloodPressure - 0,38 * rBMI - 0,26 * rTriglyceride))))))/10))"]
["pIGTToDeath","if(\r\n\trGender = 1; \r\n\tHazardRatioIGTToDeath * tMortalityWithoutDiabetes[rAge + _stage; 1]; \r\n\tHazardRatioIGTToDeath * tMortalityWithoutDiabetes[rAge + _stage; 2]\r\n)"]
["pIGTToNGT","(1-exp(-(-ln(1-(1/(1+exp((-1)*(3,06 + 0,72 * rGender - 0,07 * (rAge + _stage) - 0,23 * rEducation - 0,37\t*\trBMI-0,29 *\trPerceivedHealth - 0,49 * rTriglyceride ))))))/10))"]
["pNGTToCombined","(1-exp(-(-ln(1-(1/(1+exp((-1)*(-6,2+0,16*rGender+0,04*(rAge+_stage)-0,24*rSnus+0,32*rHeredity+0,15*rPhysicalActivity+0,2*rTriglyceride+0,6*rBloodPressure+0,5*rBMI-0,33*rFiveADay))))))/10))"]
["pNGTToDeath","if(rGender=1;tMortalityWithoutDiabetes[rAge+_stage;1];tMortalityWithoutDiabetes[rAge+_stage;2])"]
["pNGTToIFG","(1-exp(-(-ln(1-(1/(1+exp((-1)*(-3,07+0,29*rGender+0,01*(rAge+_stage)+0,11*rEducation+0,19*rHeredity-0,09*rSnus+0,15*rTriglyceride+0,12*rBloodPressure+0,16*rBMI+0,23*rSmoking))))))/10))"]
["pNGTToIGT","(1-exp(-(-ln(1-(1/(1+exp((-1)*(-7,29+0,51*rGender+0,06*(rAge+_stage)+0,09*rEducation+0,14*rPhysicalActivity+0,15*rHeredity+0,41*rTriglyceride+0,34*rBloodPressure+0,21*rBMI-0,12*rSmoking))))))/10))"]
["pT2DToDeath","if(rGender=1;HazardRatioT2DToDeath*tMortalityWithoutDiabetes[rAge+_stage;1];HazardRatioT2DToDeath*tMortalityWithoutDiabetes[rAge+_stage;2])"]
["pCombinedToNGT","(1-exp(-(-ln(1-(1/(1+exp((-1)*( - 0,61 + 0,81 * rGender + 1,15 * rSnus - 1,24 *\trSmoking - 0,77 *\trBMI\t ))))))/10))"]
["cLifestyleTxInT2D","cT2D+cLifestyleTx"]
["cMetforminTxInT2D","cT2D+cMetforminTx"]
["cSemaglutideTxInT2D","cT2D+cSemaglutideTx"]
["cTirzepatideTxInT2D","cT2D+cTirzepatideTx"]
["cLifestyleTxInCombined","cLifestyleTx+cCombined"]
["cLifestyleTxInIFG","cLifestyleTx+cIFG"]
["cLifestyleTxInIGT","cLifestyleTx+cIGT"]
["cMetforminTxInCombined","cMetforminTx+cCombined"]
["cMetforminTxInIFG","cMetforminTx+cIFG"]
["cMetforminTxInIGT","cMetforminTx+cIGT"]
["cSemaglutideTxInCombined","cSemaglutideTx+cCombined"]
["cSemaglutideTxInIFG","cSemaglutideTx+cIFG"]
["cSemaglutideTxInIGT","cSemaglutideTx+cIGT"]
["cTirzepatideTxInCombined","cTirzepatideTx+cCombined"]
["cTirzepatideTxInIFG","cTirzepatideTx+cIFG"]
["cTirzepatideTxInIGT","cTirzepatideTx+cIGT"]
["pT2DToIFGDefault","(1-exp(-(-ln(1-(1/(1+exp((-1)*(-0,34 + 0,57 * rBMI - 0,68 * rBloodPressure - 0,385 * rSmoking))))))/10))"]
["pT2DToIGTDefault","(1-exp(-(-ln(1-(1/(1+exp((-1)*(-3,37 + 1,42 * rHeredity + 1,13 * rPerceivedHealth))))))/10))"]
["pT2DToCombinedDefault","(1-exp(-(-ln(1-(1/(1+exp((-1)*(-6,8 + 1,22 * rGender + 1,49 * rPhysicalActivity + 0,63 * rEducation - 1,07 *\trPerceivedHealth))))))/10))"]
[]
["Formulas above are integrated into cohort analysis sheets in the converted Excel model."]
[]
[]
["TreeAge Pro Distributions"]
[]
["Name","Index","Type","Param1","Param2","Param3","Sampling Rate","Option","Help/Explanation"]
["distProfiles",1,"Uniform","1","16",null,"Trial","","Param 1 = low; Param 2 = high"]
[]
["Distributions are sampled in TreeAge Pro, but not in the converted Excel model."]
[]
[]
[]
["Green cells are editable"]
["Gray cells - no impact on calculation"]