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{"sheet":"Inputs & Results","index":0,"n_rows":77,"n_cols":14,"rows_kept":77,"cut":false,"hidden":false,"merged":[[15,1,15,3],[16,1,16,3],[3,1,3,13],[6,1,6,13],[7,1,7,13],[8,1,8,13],[9,1,9,13],[10,1,10,13],[11,1,11,13],[12,1,12,13],[13,1,13,13]]}
[]
[null,"Model Information"]
[null,"DESCRIPTION"]
[null,"Second Line Diabetes Medication Added to Standard Therapy in Preventing Type 2 Diabetes related Nephropathy"]
[]
[null,"STRATEGIES"]
[null,"Base case"]
[null,"---"]
[null,"Tirzepatide 15mg/Week"]
[null,"---"]
[null,"Semaglutide 1mg/Week"]
[null,"---"]
[null,"Empagliflozin 25mg/Day"]
[null,"---"]
[]
[null,"Green cells are editable"]
[null,"Gray cells - no impact on calculation"]
[null,"INPUTS",null,null,null,"MODEL RESULTS"]
[null,"Description","Value","Reference in TreeAge",null,"WTP:",100000]
[null,"Parameter Variables",null,null,null,"Strategy","Cost","Eff","Payoff 3 - \nLife expectancy"]
[null,"",0,"vQoLDeath",null,"Base case",{"$f":"'1. Strategy Calcs'!J70","v":66439.206160877933},{"$f":"'1. Strategy Calcs'!L70","v":10.2968115211041},{"$f":"'1. Strategy Calcs'!N70","v":13.388940652827944}]
[null,"Kähm K, Laxy M, Schneider U, Rogowski WH, Lhachimi SK, Holle R. Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany. Diabetes Care. 2018;41(5):971-8.",44213.85,"cFirstYearRenalDiseaseBaseCase",null,"Empagliflozin 25mg/Day",{"$f":"'4. Strategy Calcs'!J70","v":79681.987466044229},{"$f":"'4. Strategy Calcs'!L70","v":10.497986675182784},{"$f":"'4. Strategy Calcs'!N70","v":13.679763672896856}]
[null,"Kähm K, Laxy M, Schneider U, Rogowski WH, Lhachimi SK, Holle R. Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany. Diabetes Care. 2018;41(5):971-8.",31911.91,"cFollowingRenalDiseaseBaseCase",null,"Semaglutide 1mg/Week",{"$f":"'3. Strategy Calcs'!J70","v":84311.631816334193},{"$f":"'3. Strategy Calcs'!L70","v":10.591547518253662},{"$f":"'3. Strategy Calcs'!N70","v":13.775148665481542}]
[null,"0 = Male; 1 = Female for internal use in risk equations",0,"rGender",null,"Tirzepatide 15mg/Week",{"$f":"'2. Strategy Calcs'!J70","v":156011.8456846161},{"$f":"'2. Strategy Calcs'!L70","v":10.769227025326433},{"$f":"'2. Strategy Calcs'!N70","v":14.019523435813065}]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",0,"rSmoker"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",8.3000000000000007,"rHbA1c"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",136.5,"rSBP",null,"Category","Strategy","Cost","Incr. Cost","Eff","Incr. Eff","ICER","NMB","CE"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",32.200000000000003,"rBMI",null,"Undominated","Base case",66439.206160877933,null,10.2968115211041,null,null,{"$f":"J28*WTP - H28","v":963241.94594953209},6452.4057786923377]
[null,"Kähm K, Laxy M, Schneider U, Rogowski WH, Lhachimi SK, Holle R. Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany. Diabetes Care. 2018;41(5):971-8.",8615.75,"cFirstYearMacroalbuminuriaBaseCase",null,"Undominated","Semaglutide 1mg/Week",84311.631816334193,17872.42565545626,10.591547518253662,0.29473599714956222,60638.760885345786,{"$f":"J29*WTP - H29","v":974843.12000903196},7960.2750845454848]
[null,"Kähm K, Laxy M, Schneider U, Rogowski WH, Lhachimi SK, Holle R. Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany. Diabetes Care. 2018;41(5):971-8.",8615.75,"cFirstYearMicroalbuminuriaBaseCase",null,"Undominated","Tirzepatide 15mg/Week",156011.8456846161,71700.213868281906,10.769227025326433,0.1776795070727708,403536.76712371904,{"$f":"J30*WTP - H30","v":920910.85684802709},14486.819278460434]
[null,"Kähm K, Laxy M, Schneider U, Rogowski WH, Lhachimi SK, Holle R. Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany. Diabetes Care. 2018;41(5):971-8.",7109.76,"cFollowingMacroalbuminuriaBaseCase",null,"Ext. dominated","Empagliflozin 25mg/Day",79681.987466044229,null,10.497986675182784,null,null,{"$f":"J31*WTP - H31","v":970116.68005223409},7590.2160987127436]
[null,"Kähm K, Laxy M, Schneider U, Rogowski WH, Lhachimi SK, Holle R. Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany. Diabetes Care. 2018;41(5):971-8.",7109.76,"cFollowingMicroalbuminuriaBaseCase"]
[null,"Kähm K, Laxy M, Schneider U, Rogowski WH, Lhachimi SK, Holle R. Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany. Diabetes Care. 2018;41(5):971-8.",3772.48,"cT2DBaseCase"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",62.8,"rAge"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",0,"risBlack"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",0,"risHispanic"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",0,"rCVDHistory"]
[null,"Assumption as effect is considered elsewhere in the model.",0,"rBPDrugs"]
[null,"Assumption as effect is considered elsewhere in the model.",1,"rOralT2DDrugs"]
[null,"Assumption as effect is considered elsewhere in the model.",0,"rAnticoagulants"]
[null,"Assumption as effect is considered elsewhere in the model.",0,"rAntiHypertensiveDrugs"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",183.2,"rTotalCholesterol"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",41.8,"rHDL"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",0.9,"rSerumCreatinine"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",99.2,"rUrinAlbumin_Creatinine"]
[null,"Prescribing information Mounjaro;(Inkonsistent mit: Ludvik B, Giorgino F, Jódar E, Frias JP, Fernández Landó L, Brown K, et al. Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial. The Lancet. 2021;398(10300):583-98.",-2.2999999999999998,"rHbA1c_Tirzepatide"]
[null,"Prescribing information Mounjaro; Ludvik B, Giorgino F, Jódar E, Frias JP, Fernández Landó L, Brown K, et al. Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial. The Lancet. 2021;398(10300):583-98.",4.8,"rHDL_Tirzepatide"]
[null,"Prescribing information Mounjaro; Ludvik B, Giorgino F, Jódar E, Frias JP, Fernández Landó L, Brown K, et al. Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial. The Lancet. 2021;398(10300):583-98.",-10.4,"rTotalCholesterol_Tirzepatide"]
[null,"Prescribing information NovoNordisk Ozempic; Ahrén B, Masmiquel L, Kumar H, Sargin M, Karsbøl JD, Jacobsen SH, Chow F. Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial. Lancet Diabetes Endocrinol. 2017 May;5(5):341-354. doi: 10.1016/S2213-8587(17)30092-X. Epub 2017 Apr 3. PMID: 28385659.",-1.5,"rHbA1c_Semaglutide1mg"]
[null,"Davies M, Færch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L, Rosenstock J, Shimomura I, Viljoen A, Wadden TA, Lingvay I; STEP 2 Study Group. Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet. 2021 Mar 13;397(10278):971-984. doi: 10.1016/S0140-6736(21)00213-0. Epub 2021 Mar 2. PMID: 33667417.",2.5099999999999998,"rHDL_Semaglutide1mg"]
[null,"Davies M, Færch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L, Rosenstock J, Shimomura I, Viljoen A, Wadden TA, Lingvay I; STEP 2 Study Group. Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet. 2021 Mar 13;397(10278):971-984. doi: 10.1016/S0140-6736(21)00213-0. Epub 2021 Mar 2. PMID: 33667417.",-4.0199999999999996,"rTotalCholesterol_Semaglutide1mg"]
[null,"Assumption: 15mg/week, last accessed: 11.11.2025 https://www.shop-apotheke.com/arzneimittel/18253693/mounjaro-15-mg-dosis-kwikpen-inj-lsg-fertigpen.htm",6261.84,"cTirzepatideTx"]
[null,"Assumption: 1mg/week Ozempic, last accessed: 11.11.2025 https://www.shop-apotheke.com/arzneimittel/19904158/ozempic-1-mg-injektionsloesg-im-fertigpen-8-wochen.htm?position=3&query=ozepmi&queryID=07ffbac16c5a8b5e559a5d5ddbf1d8d7&eventName=click+on+product+in+suggest&eventType=click&objectIDs=%5B19904158%5D",1283.75,"cSemaglutide1mgTx"]
[null,"Zinman, Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes",-0.36,"rHbA1c_Empagliflozin"]
[null,"Assumption: 25mg/day, last accessed: 04.11.2025 https://www.shop-apotheke.com/arzneimittel/10262132/jardiance-25-mg.htm?position=4&query=Empagliflozin+&queryID=79e83702696ea23012196877f3a6981c&eventName=click+on+product+in+suggest&eventType=click&objectIDs=%5B10262132%5D",694.92,"cEmpagliflozinTx"]
[null,"Emanuelsson 2025 Effect of empagliflozin on plasma lipids and lipoproteins in type 2 diabetes and heart failure – Empire HF and SIMPLE",0,"rHDL_Empagliflozin"]
[null,"Emanuelsson F, Jensen J, Omar M, Jürgens M, Kistorp C, Brandt-Jacobsen NH, et al. Effect of empagliflozin on plasma lipids and lipoproteins in type 2 diabetes and heart failure - Empire HF and SIMPLE. J Clin Lipidol. 2025;19(2):276-85.",0,"rTotalCholesterol_Empagliflozin"]
[null,"Assumption: 2,4mg/week Wegovy last accessed: 17.11.2205 https://www.shop-apotheke.com/arzneimittel/18299347/wegovy-2-4-mg-flextouch-injektionslsg-fertigpen.htm?eventName=click+on+product+list+item&position=1&query=semaglutide&queryID=cdcdb95a45e17e361228951da73ff51c&eventType=click&objectIDs=%5B18299347%5D",3598.79,"cSemaglutideTx2_4mg"]
[null,"Prescribing information NovoNordisk Wegovy; Davies M, Færch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L, Rosenstock J, Shimomura I, Viljoen A, Wadden TA, Lingvay I; STEP 2 Study Group. Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet. 2021 Mar 13;397(10278):971-984. doi: 10.1016/S0140-6736(21)00213-0. Epub 2021 Mar 2. PMID: 33667417.",-1.6,"rHbA1c_Semaglutide2_4mg"]
[null,"Prescribing information NovoNordisk Wegovy; Davies M, Færch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L, Rosenstock J, Shimomura I, Viljoen A, Wadden TA, Lingvay I; STEP 2 Study Group. Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet. 2021 Mar 13;397(10278):971-984. doi: 10.1016/S0140-6736(21)00213-0. Epub 2021 Mar 2. PMID: 33667417.",5.14,"rHDL_Semaglutide2_4mg"]
[null,"Prescribing information NovoNordisk Wegovy; Davies M, Færch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L, Rosenstock J, Shimomura I, Viljoen A, Wadden TA, Lingvay I; STEP 2 Study Group. Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet. 2021 Mar 13;397(10278):971-984. doi: 10.1016/S0140-6736(21)00213-0. Epub 2021 Mar 2. PMID: 33667417.",-2.39,"rTotalCholesterol_Semaglutide2_4mg"]
[null,"Hazard Ratio used to model impact of treatment related remission specified in each submodel sperately.",1,"vHR_Intervention_MicroMacro (Defined in node Base case)"]
[null,"Factor used to model impact of treatment related HbA1c change specified in each submodel seperately.",1,"vFactorHbA1cChange (Defined in node Base case)"]
[null,"",1,"vHR_Intervention_RenalDeath (Defined in node Base case)"]
[null,"",1,"vHR_Intervention_MacroRenal (Defined in node Base case)"]
[null,"Hazard Ratio used to model impact of treatment related remission specified in each submodel sperately.",0.57999999999999996,"vHR_Intervention_MicroMacro (Defined in node Tirzepatide 15mg/Week)"]
[null,"Factor used to model impact of treatment related HbA1c change specified in each submodel seperately.",2.2777770743815609,"vFactorHbA1cChange (Defined in node Tirzepatide 15mg/Week)"]
[null,"",0.57999999999999996,"vHR_Intervention_RenalDeath (Defined in node Tirzepatide 15mg/Week)"]
[null,"",0.57999999999999996,"vHR_Intervention_MacroRenal (Defined in node Tirzepatide 15mg/Week)"]
[null,"Hazard Ratio used to model impact of treatment related remission specified in each submodel sperately.",0.79,"vHR_Intervention_MicroMacro (Defined in node Semaglutide 1mg/Week)"]
[null,"Factor used to model impact of treatment related HbA1c change specified in each submodel seperately.",1.7311743616891002,"vFactorHbA1cChange (Defined in node Semaglutide 1mg/Week)"]
[null,"",0.79,"vHR_Intervention_RenalDeath (Defined in node Semaglutide 1mg/Week)"]
[null,"",0.79,"vHR_Intervention_MacroRenal (Defined in node Semaglutide 1mg/Week)"]
[null,"Hazard Ratio used to model impact of treatment related remission specified in each submodel sperately.",0.61,"vHR_Intervention_MicroMacro (Defined in node Empagliflozin 25mg/Day)"]
[null,"Factor used to model impact of treatment related HbA1c change specified in each submodel seperately.",1.4857504527606404,"vFactorHbA1cChange (Defined in node Empagliflozin 25mg/Day)"]
[null,"",0.61,"vHR_Intervention_RenalDeath (Defined in node Empagliflozin 25mg/Day)"]
[null,"",0.61,"vHR_Intervention_MacroRenal (Defined in node Empagliflozin 25mg/Day)"]

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[null,"Strategy",1,"Base case"]
[null,"States","All"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"T2D - State 1.1",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Microalbuminuria - State 1.2",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Macroalbuminuria - State 1.3",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Renal Disease - State 1.4",null,null,null,null,null,null,null,null,null,null,null,null,"Death - State 1.5"]
[null,null,null,"Cohort State Proportions",null,null,null,null,null,null,null,null,null,null,null,null,null,"Cohort %",null,null,null,null,null,null,"Payoff 1 - Cost",null,null,"Payoff 2 - QALY",null,null,"Payoff 3 - Life expectancy",null,null,"Cohort %",null,null,null,null,null,"Payoff 1 - Cost",null,null,null,"Payoff 2 - QALY",null,null,"Payoff 3 - Life expectancy",null,null,"Cohort %",null,null,null,null,"Payoff 1 - Cost",null,null,null,"Payoff 2 - QALY",null,null,"Payoff 3 - Life expectancy",null,null,"Cohort %",null,null,"Payoff 1 - Cost",null,null,null,"Payoff 2 - QALY",null,null,"Payoff 3 - Life expectancy",null,null,"Cohort %",null,"Payoff 2 - QALY"]
[null,"Cycle",null,"T2D","Microalbuminuria","Macroalbuminuria","Renal Disease","Death","Payoff 1 - Cost",null,"Payoff 2 - QALY",null,"Payoff 3 - Life expectancy",null,null,"Checksum of Cohort %",null,"1.1\n State","1.1.1\n Transition","1.1.1.1\n Transition","1.1.1.2\n Transition","1.1.1.3\n Transition","1.1.1.4\n Transition","1.1.2\n Transition","1.1\nState before WCC","1.1\nState after WCC","State/Trans","1.1\nState before WCC","1.1\nState after WCC","State/Trans","1.1\nState before WCC","1.1\nState after WCC","State/Trans","1.2\n State","1.2.1\n Transition","1.2.1.1\n Transition","1.2.1.2\n Transition","1.2.1.3\n Transition","1.2.2\n Transition","1.2\nState before WCC","1.2\nState after WCC","1.2\nState StartUp and Event","State/Trans","1.2\nState before WCC","1.2\nState after WCC","State/Trans","1.2\nState before WCC","1.2\nState after WCC","State/Trans","1.3\n State","1.3.1\n Transition","1.3.1.1\n Transition","1.3.1.2\n Transition","1.3.2\n Transition","1.3\nState before WCC","1.3\nState after WCC","1.3\nState StartUp and Event","State/Trans","1.3\nState before WCC","1.3\nState after WCC","State/Trans","1.3\nState before WCC","1.3\nState after WCC","State/Trans","1.4\n State","1.4.1\n Transition","1.4.2\n Transition","1.4\nState before WCC","1.4\nState after WCC","1.4\nState StartUp and Event","State/Trans","1.4\nState before WCC","1.4\nState after WCC","State/Trans","1.4\nState before WCC","1.4\nState after WCC","State/Trans","1.5\n State","1.5.1\n Transition","1.5\nState before WCC","1.5\nState after WCC","State/Trans",null,"pMacroalbuminuriaToDeath","pMicroalbuminuriaToDeath","pT2DToDeath","vQoLMacro","vQoLMicro","vQoLRenalDisease","vQoLT2D"]
[null,null,null,null,null,null,null,null,"WCC Disc","Cum Disc","WCC Disc","Cum Disc","WCC Disc","Cum Disc",null,null,null,"T2D","Alive","Stay in T2D","Microalbuminuria","Macroalbuminuria","Renal Disease","Dead","T2D","T2D","State Total","T2D","T2D","State Total","T2D","T2D","State Total","Microalbuminuria","Alive","Stay in Microalbuminuria","T2D","Macroalbuminuria","Dead","Microalbuminuria","Microalbuminuria","Microalbuminuria","State Total","Microalbuminuria","Microalbuminuria","State Total","Microalbuminuria","Microalbuminuria","State Total","Macroalbuminuria","Alive","Stay in Macroalbuminuria","Renal Disease","Dead","Macroalbuminuria","Macroalbuminuria","Macroalbuminuria","State Total","Macroalbuminuria","Macroalbuminuria","State Total","Macroalbuminuria","Macroalbuminuria","State Total","Renal Disease","Stay in Renal Disease","Dead","Renal Disease","Renal Disease","Renal Disease","State Total","Renal Disease","Renal Disease","State Total","Renal Disease","Renal Disease","State Total","Death","Dead","Death","Death","State Total"]
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[null,"Strategy",2,"Tirzepatide 15mg/Week"]
[null,"States","All"]
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["Green cells are editable"]
["Changing this may require manual changes to Excel formulas"]

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[null,"Original Data from TreeAge Pro Model"]
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[null,"Kähm K, Laxy M, Schneider U, Rogowski WH, Lhachimi SK, Holle R. Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany. Diabetes Care. 2018;41(5):971-8.",44213.85,"cFirstYearRenalDiseaseBaseCase",null,null,{"$f":"'Inputs & Results'!F23","v":"Semaglutide 1mg/Week"},{"$f":"'Inputs & Results'!G23","v":84311.631816334193},{"$f":"'Inputs & Results'!H23","v":10.591547518253662},{"$f":"'Inputs & Results'!I23","v":13.775148665481542}]
[null,"Kähm K, Laxy M, Schneider U, Rogowski WH, Lhachimi SK, Holle R. Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany. Diabetes Care. 2018;41(5):971-8.",31911.91,"cFollowingRenalDiseaseBaseCase",null,null,{"$f":"'Inputs & Results'!F24","v":"Tirzepatide 15mg/Week"},{"$f":"'Inputs & Results'!G24","v":156011.8456846161},{"$f":"'Inputs & Results'!H24","v":10.769227025326433},{"$f":"'Inputs & Results'!I24","v":14.019523435813065}]
[null,"0 = Male; 1 = Female for internal use in risk equations",0,"rGender"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",0,"rSmoker",null,null,"ORIGINAL MODEL RESULTS FROM EXCEL"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",8.3000000000000007,"rHbA1c",null,null,"Strategy","Cost","Eff","Payoff 3 - \nLife expectancy"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",136.5,"rSBP",null,null,"Base case",66439.206160877933,10.2968115211041,13.388940652827944]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",32.200000000000003,"rBMI",null,null,"Empagliflozin 25mg/Day",79681.987466044229,10.497986675182784,13.679763672896856]
[null,"Kähm K, Laxy M, Schneider U, Rogowski WH, Lhachimi SK, Holle R. Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany. Diabetes Care. 2018;41(5):971-8.",8615.75,"cFirstYearMacroalbuminuriaBaseCase",null,null,"Semaglutide 1mg/Week",84311.631816334193,10.591547518253662,13.775148665481542]
[null,"Kähm K, Laxy M, Schneider U, Rogowski WH, Lhachimi SK, Holle R. Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany. Diabetes Care. 2018;41(5):971-8.",8615.75,"cFirstYearMicroalbuminuriaBaseCase",null,null,"Tirzepatide 15mg/Week",156011.8456846161,10.769227025326433,14.019523435813065]
[null,"Kähm K, Laxy M, Schneider U, Rogowski WH, Lhachimi SK, Holle R. Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany. Diabetes Care. 2018;41(5):971-8.",7109.76,"cFollowingMacroalbuminuriaBaseCase"]
[null,"Kähm K, Laxy M, Schneider U, Rogowski WH, Lhachimi SK, Holle R. Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany. Diabetes Care. 2018;41(5):971-8.",7109.76,"cFollowingMicroalbuminuriaBaseCase",null,null,"ORIGINAL MODEL RESULTS FROM TREEAGE PRO"]
[null,"Kähm K, Laxy M, Schneider U, Rogowski WH, Lhachimi SK, Holle R. Health Care Costs Associated With Incident Complications in Patients With Type 2 Diabetes in Germany. Diabetes Care. 2018;41(5):971-8.",3772.48,"cT2DBaseCase",null,null,"Strategy","Cost","Eff","Payoff 3 - \nLife expectancy"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",62.8,"rAge",null,null,"Base case",66439.206160877919,10.2968115211041,13.388940652827944]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",0,"risBlack",null,null,"Empagliflozin 25mg/Day",79681.987466044186,10.497986675182785,13.679763672896849]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",0,"risHispanic",null,null,"Semaglutide 1mg/Week",84311.631816334164,10.591547518253659,13.77514866548154]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",0,"rCVDHistory",null,null,"Tirzepatide 15mg/Week",156011.8456846161,10.769227025326423,14.019523435813054]
[null,"Assumption as effect is considered elsewhere in the model.",0,"rBPDrugs"]
[null,"Assumption as effect is considered elsewhere in the model.",1,"rOralT2DDrugs"]
[null,"Assumption as effect is considered elsewhere in the model.",0,"rAnticoagulants"]
[null,"Assumption as effect is considered elsewhere in the model.",0,"rAntiHypertensiveDrugs"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",183.2,"rTotalCholesterol"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",41.8,"rHDL"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",0.9,"rSerumCreatinine"]
[null,"ACCORD Trial as listed in Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS. Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Lancet Diabetes Endocrinol.",99.2,"rUrinAlbumin_Creatinine"]
[null,"Prescribing information Mounjaro;(Inkonsistent mit: Ludvik B, Giorgino F, Jódar E, Frias JP, Fernández Landó L, Brown K, et al. Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial. The Lancet. 2021;398(10300):583-98.",-2.2999999999999998,"rHbA1c_Tirzepatide"]
[null,"Prescribing information Mounjaro; Ludvik B, Giorgino F, Jódar E, Frias JP, Fernández Landó L, Brown K, et al. Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial. The Lancet. 2021;398(10300):583-98.",4.8,"rHDL_Tirzepatide"]
[null,"Prescribing information Mounjaro; Ludvik B, Giorgino F, Jódar E, Frias JP, Fernández Landó L, Brown K, et al. Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial. The Lancet. 2021;398(10300):583-98.",-10.4,"rTotalCholesterol_Tirzepatide"]
[null,"Prescribing information NovoNordisk Ozempic; Ahrén B, Masmiquel L, Kumar H, Sargin M, Karsbøl JD, Jacobsen SH, Chow F. Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial. Lancet Diabetes Endocrinol. 2017 May;5(5):341-354. doi: 10.1016/S2213-8587(17)30092-X. Epub 2017 Apr 3. PMID: 28385659.",-1.5,"rHbA1c_Semaglutide1mg"]
[null,"Davies M, Færch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L, Rosenstock J, Shimomura I, Viljoen A, Wadden TA, Lingvay I; STEP 2 Study Group. Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet. 2021 Mar 13;397(10278):971-984. doi: 10.1016/S0140-6736(21)00213-0. Epub 2021 Mar 2. PMID: 33667417.",2.5099999999999998,"rHDL_Semaglutide1mg"]
[null,"Davies M, Færch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L, Rosenstock J, Shimomura I, Viljoen A, Wadden TA, Lingvay I; STEP 2 Study Group. Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet. 2021 Mar 13;397(10278):971-984. doi: 10.1016/S0140-6736(21)00213-0. Epub 2021 Mar 2. PMID: 33667417.",-4.0199999999999996,"rTotalCholesterol_Semaglutide1mg"]
[null,"Assumption: 15mg/week, last accessed: 11.11.2025 https://www.shop-apotheke.com/arzneimittel/18253693/mounjaro-15-mg-dosis-kwikpen-inj-lsg-fertigpen.htm",6261.84,"cTirzepatideTx"]
[null,"Assumption: 1mg/week Ozempic, last accessed: 11.11.2025 https://www.shop-apotheke.com/arzneimittel/19904158/ozempic-1-mg-injektionsloesg-im-fertigpen-8-wochen.htm?position=3&query=ozepmi&queryID=07ffbac16c5a8b5e559a5d5ddbf1d8d7&eventName=click+on+product+in+suggest&eventType=click&objectIDs=%5B19904158%5D",1283.75,"cSemaglutide1mgTx"]
[null,"Zinman, Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes",-0.36,"rHbA1c_Empagliflozin"]
[null,"Assumption: 25mg/day, last accessed: 04.11.2025 https://www.shop-apotheke.com/arzneimittel/10262132/jardiance-25-mg.htm?position=4&query=Empagliflozin+&queryID=79e83702696ea23012196877f3a6981c&eventName=click+on+product+in+suggest&eventType=click&objectIDs=%5B10262132%5D",694.92,"cEmpagliflozinTx"]
[null,"Emanuelsson 2025 Effect of empagliflozin on plasma lipids and lipoproteins in type 2 diabetes and heart failure – Empire HF and SIMPLE",0,"rHDL_Empagliflozin"]
[null,"Emanuelsson F, Jensen J, Omar M, Jürgens M, Kistorp C, Brandt-Jacobsen NH, et al. Effect of empagliflozin on plasma lipids and lipoproteins in type 2 diabetes and heart failure - Empire HF and SIMPLE. J Clin Lipidol. 2025;19(2):276-85.",0,"rTotalCholesterol_Empagliflozin"]
[null,"Assumption: 2,4mg/week Wegovy last accessed: 17.11.2205 https://www.shop-apotheke.com/arzneimittel/18299347/wegovy-2-4-mg-flextouch-injektionslsg-fertigpen.htm?eventName=click+on+product+list+item&position=1&query=semaglutide&queryID=cdcdb95a45e17e361228951da73ff51c&eventType=click&objectIDs=%5B18299347%5D",3598.79,"cSemaglutideTx2_4mg"]
[null,"Prescribing information NovoNordisk Wegovy; Davies M, Færch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L, Rosenstock J, Shimomura I, Viljoen A, Wadden TA, Lingvay I; STEP 2 Study Group. Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet. 2021 Mar 13;397(10278):971-984. doi: 10.1016/S0140-6736(21)00213-0. Epub 2021 Mar 2. PMID: 33667417.",-1.6,"rHbA1c_Semaglutide2_4mg"]
[null,"Prescribing information NovoNordisk Wegovy; Davies M, Færch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L, Rosenstock J, Shimomura I, Viljoen A, Wadden TA, Lingvay I; STEP 2 Study Group. Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet. 2021 Mar 13;397(10278):971-984. doi: 10.1016/S0140-6736(21)00213-0. Epub 2021 Mar 2. PMID: 33667417.",5.14,"rHDL_Semaglutide2_4mg"]
[null,"Prescribing information NovoNordisk Wegovy; Davies M, Færch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L, Rosenstock J, Shimomura I, Viljoen A, Wadden TA, Lingvay I; STEP 2 Study Group. Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet. 2021 Mar 13;397(10278):971-984. doi: 10.1016/S0140-6736(21)00213-0. Epub 2021 Mar 2. PMID: 33667417.",-2.39,"rTotalCholesterol_Semaglutide2_4mg"]
[null,"Hazard Ratio used to model impact of treatment related remission specified in each submodel sperately.",1,"vHR_Intervention_MicroMacro (Defined in node Base case)"]
[null,"Factor used to model impact of treatment related HbA1c change specified in each submodel seperately.",1,"vFactorHbA1cChange (Defined in node Base case)"]
[null,"",1,"vHR_Intervention_RenalDeath (Defined in node Base case)"]
[null,"",1,"vHR_Intervention_MacroRenal (Defined in node Base case)"]
[null,"Hazard Ratio used to model impact of treatment related remission specified in each submodel sperately.",0.57999999999999996,"vHR_Intervention_MicroMacro (Defined in node Tirzepatide 15mg/Week)"]
[null,"Factor used to model impact of treatment related HbA1c change specified in each submodel seperately.",2.2777770743815609,"vFactorHbA1cChange (Defined in node Tirzepatide 15mg/Week)"]
[null,"",0.57999999999999996,"vHR_Intervention_RenalDeath (Defined in node Tirzepatide 15mg/Week)"]
[null,"",0.57999999999999996,"vHR_Intervention_MacroRenal (Defined in node Tirzepatide 15mg/Week)"]
[null,"Hazard Ratio used to model impact of treatment related remission specified in each submodel sperately.",0.79,"vHR_Intervention_MicroMacro (Defined in node Semaglutide 1mg/Week)"]
[null,"Factor used to model impact of treatment related HbA1c change specified in each submodel seperately.",1.7311743616891002,"vFactorHbA1cChange (Defined in node Semaglutide 1mg/Week)"]
[null,"",0.79,"vHR_Intervention_RenalDeath (Defined in node Semaglutide 1mg/Week)"]
[null,"",0.79,"vHR_Intervention_MacroRenal (Defined in node Semaglutide 1mg/Week)"]
[null,"Hazard Ratio used to model impact of treatment related remission specified in each submodel sperately.",0.61,"vHR_Intervention_MicroMacro (Defined in node Empagliflozin 25mg/Day)"]
[null,"Factor used to model impact of treatment related HbA1c change specified in each submodel seperately.",1.4857504527606404,"vFactorHbA1cChange (Defined in node Empagliflozin 25mg/Day)"]
[null,"",0.61,"vHR_Intervention_RenalDeath (Defined in node Empagliflozin 25mg/Day)"]
[null,"",0.61,"vHR_Intervention_MacroRenal (Defined in node Empagliflozin 25mg/Day)"]

{"sheet":"Time Discounting","index":8,"n_rows":65,"n_cols":8,"rows_kept":65,"cut":false,"hidden":false,"merged":[]}
["Global Discounting"]
[]
["Cycle",null,"Payoff 1 - \nCost","Payoff 1 - \nCost\n(Transition)","Payoff 2 - \nQALY","Payoff 2 - \nQALY\n(Transition)","Payoff 3 - \nLife expectancy","Payoff 3 - \nLife expectancy\n(Transition)"]
[]
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[34,null,0.36604489974263904,0.36067475683913502,0.36604489974263904,0.36067475683913502,0.36604489974263904,0.36067475683913502]
[35,null,0.35538339780838735,0.35016966683411171,0.35538339780838735,0.35016966683411171,0.35538339780838735,0.35016966683411171]
[36,null,0.34503242505668674,0.33997055032438023,0.34503242505668674,0.33997055032438023,0.34503242505668674,0.33997055032438023]
[37,null,0.33498293694823961,0.33006849546056333,0.33498293694823961,0.33006849546056333,0.33498293694823961,0.33006849546056333]
[38,null,0.3252261523769317,0.32045484996171203,0.3252261523769317,0.32045484996171203,0.3252261523769317,0.32045484996171203]
[39,null,0.31575354599702099,0.31112121355506017,0.31575354599702099,0.31112121355506017,0.31575354599702099,0.31112121355506017]
[40,null,0.30655684077380685,0.30205943063598073,0.30655684077380685,0.30205943063598073,0.30655684077380685,0.30205943063598073]
[41,null,0.29762800075126877,0.29326158314172884,0.29762800075126877,0.29326158314172884,0.29762800075126877,0.29326158314172884]
[42,null,0.28895922403035801,0.28471998363274642,0.28895922403035801,0.28471998363274642,0.28895922403035801,0.28471998363274642]
[43,null,0.28054293595180391,0.27642716857548194,0.28054293595180391,0.27642716857548194,0.28054293595180391,0.27642716857548194]
[44,null,0.27237178247747956,0.2683758918208563,0.27237178247747956,0.2683758918208563,0.27237178247747956,0.2683758918208563]
[45,null,0.26443862376454325,0.26055911827267597,0.26443862376454325,0.26055911827267597,0.26443862376454325,0.26055911827267597]
[46,null,0.25673652792674101,0.25297001774046213,0.25673652792674101,0.25297001774046213,0.25673652792674101,0.25297001774046213]
[47,null,0.24925876497741845,0.24560195897132245,0.24925876497741845,0.24560195897132245,0.24925876497741845,0.24560195897132245]
[48,null,0.24199880094894996,0.23844850385565286,0.24199880094894996,0.23844850385565286,0.24199880094894996,0.23844850385565286]
[49,null,0.2349502921834466,0.2315034018016047,0.2349502921834466,0.2315034018016047,0.2349502921834466,0.2315034018016047]
[50,null,0.22810707978975397,0.22476058427340265,0.22810707978975397,0.22476058427340265,0.22810707978975397,0.22476058427340265]
[51,null,0.22146318426189707,0.2182141594887404,0.22146318426189707,0.2182141594887404,0.22146318426189707,0.2182141594887404]
[52,null,0.215012800254269,0.21185840727062175,0.215012800254269,0.21185840727062175,0.215012800254269,0.21185840727062175]
[53,null,0.20875029150899907,0.20568777404914737,0.20875029150899907,0.20568777404914737,0.20875029150899907,0.20568777404914737]
[54,null,0.20267018593106703,0.19969686800888092,0.20267018593106703,0.19969686800888092,0.20267018593106703,0.19969686800888092]
[55,null,0.19676717080686118,0.19388045437755425,0.19676717080686118,0.19388045437755425,0.19676717080686118,0.19388045437755425]
[56,null,0.19103608816200118,0.18823345085199444,0.19103608816200118,0.18823345085199444,0.19103608816200118,0.18823345085199444]
[57,null,0.18547193025437006,0.18275092315727612,0.18547193025437006,0.18275092315727612,0.18547193025437006,0.18275092315727612]
[58,null,0.18006983519841754,0.17742808073521951,0.18006983519841754,0.17742808073521951,0.18006983519841754,0.17742808073521951]
[59,null,0.17482508271691022,0.1722602725584656,0.17482508271691022,0.1722602725584656,0.17482508271691022,0.1722602725584656]
[60,null,0.1697330900164177,0.16724298306647142,0.1697330900164177,0.16724298306647142,0.1697330900164177,0.16724298306647142]

{"sheet":"TP Internal Formulas","index":9,"n_rows":90,"n_cols":3,"rows_kept":90,"cut":false,"hidden":true,"merged":[[89,0,89,2],[2,0,2,10],[3,0,3,10],[66,0,66,10],[84,0,84,10],[88,0,88,2]]}
["EXTRAS"]
[]
["This worksheet includes elements from the TreeAge Pro model that are not actively used in the exported Excel model."]
["They are included here for reference only."]
[]
["TreeAge Pro Variable Sensitivity Analysis Range"]
[]
["Name","Low","High"]
["vQoLDeath",0,0]
["cFirstYearRenalDiseaseBaseCase",0.1,0.1]
["cFollowingRenalDiseaseBaseCase",0.1,0.1]
["rGender",0,1]
["rSmoker",0,1]
["rHbA1c",0.1,0.1]
["rSBP",0.1,0.1]
["rBMI",0.1,0.1]
["cFirstYearMacroalbuminuriaBaseCase",0.1,0.1]
["cFirstYearMicroalbuminuriaBaseCase",0.1,0.1]
["cFollowingMacroalbuminuriaBaseCase",0.1,0.1]
["cFollowingMicroalbuminuriaBaseCase",0.1,0]
["cT2DBaseCase",0.1,0.1]
["rAge",0.1,0.1]
["risBlack",0,1]
["risHispanic",0,1]
["rCVDHistory",0,1]
["rBPDrugs",0,1]
["rOralT2DDrugs",0,1]
["rAnticoagulants",0,1]
["rAntiHypertensiveDrugs",0,1]
["rTotalCholesterol",0.1,0.1]
["rHDL",0.1,0.1]
["rSerumCreatinine",0.1,0.1]
["rUrinAlbumin_Creatinine",0.1,0.1]
["rHbA1c_Tirzepatide",-2.5299999999999998,-2.0699999999999998]
["rHDL_Tirzepatide",0.1,0.1]
["rTotalCholesterol_Tirzepatide",-11.44,-9.36]
["rHbA1c_Semaglutide1mg",-1.65,-1.35]
["rHDL_Semaglutide1mg",0.1,0.1]
["rTotalCholesterol_Semaglutide1mg",-4.4219999999999997,-3.6179999999999999]
["cTirzepatideTx",0.1,0.1]
["cSemaglutide1mgTx",0.1,0.1]
["rHbA1c_Empagliflozin",-0.39600000000000002,-0.32400000000000001]
["cEmpagliflozinTx",0.1,0.1]
["rHDL_Empagliflozin",0.1,0.1]
["rTotalCholesterol_Empagliflozin",0.1,0.1]
["cSemaglutideTx2_4mg",0.1,0.1]
["rHbA1c_Semaglutide2_4mg",0.1,0.1]
["rHDL_Semaglutide2_4mg",0.1,0.1]
["rTotalCholesterol_Semaglutide2_4mg",0.1,0.1]
["vHR_Intervention_MicroMacro (Defined in node Base case)",0.1,0.1]
["vFactorHbA1cChange (Defined in node Base case)"]
["vHR_Intervention_RenalDeath (Defined in node Base case)",0.1,0.1]
["vHR_Intervention_MacroRenal (Defined in node Base case)",0.1,0.1]
["vHR_Intervention_MicroMacro (Defined in node Tirzepatide 15mg/Week)",0.1,0.1]
["vFactorHbA1cChange (Defined in node Tirzepatide 15mg/Week)"]
["vHR_Intervention_RenalDeath (Defined in node Tirzepatide 15mg/Week)",0.1,0.1]
["vHR_Intervention_MacroRenal (Defined in node Tirzepatide 15mg/Week)",0.1,0.1]
["vHR_Intervention_MicroMacro (Defined in node Semaglutide 1mg/Week)",0.1,0.1]
["vFactorHbA1cChange (Defined in node Semaglutide 1mg/Week)"]
["vHR_Intervention_RenalDeath (Defined in node Semaglutide 1mg/Week)",0.1,0.1]
["vHR_Intervention_MacroRenal (Defined in node Semaglutide 1mg/Week)",0.1,0.1]
["vHR_Intervention_MicroMacro (Defined in node Empagliflozin 25mg/Day)",0.1,0.1]
["vFactorHbA1cChange (Defined in node Empagliflozin 25mg/Day)"]
["vHR_Intervention_RenalDeath (Defined in node Empagliflozin 25mg/Day)",0.1,0.1]
["vHR_Intervention_MacroRenal (Defined in node Empagliflozin 25mg/Day)",0.1,0.1]
[]
["Sensitivity analysis ranges are used in TreeAge Pro, but not in the converted Excel model."]
[]
[]
["TreeAge Pro Variable Formulas"]
[]
["Name","Value"]
["pMacroalbuminuriaToDeath","pT2DToDeath*2,47"]
["pMicroalbuminuriaToDeath","if(rAge <64;\tpT2DToDeath * 2,30 ; pT2DToDeath\t* 1,70 )"]
["pMicroalbuminuriaToT2D","(1-pMicroalbuminuriaToDeath)*0,072*vFactorHbA1cChange *1"]
["pT2DToDeath","if(rGender=0;tGeneralMortWONephropathy_2023[rAge+_stage;1];tGeneralMortWONephropathy_2023[rAge+_stage;2])"]
["vQoLMacro","if (rGender =\t1;\t0,742 - tQoL_AgeDecrements[_stage;\t1] - 0,093;\t0,742 - tQoL_AgeDecrements[_stage;\t1])"]
["vQoLMicro","if (rGender =1;0,790 - tQoL_AgeDecrements[_stage;1] - 0,093;0,790 - tQoL_AgeDecrements[_stage;1])"]
["vQoLRenalDisease","if (rGender =\t1;\t0,615 - tQoL_AgeDecrements[_stage;\t1] - 0,093;\t0,615 - tQoL_AgeDecrements[_stage;\t1])"]
["vQoLT2D","if (rGender =\t1\t;\t0,790 - tQoL_AgeDecrements[_stage;\t1] - 0,093;\t0,790 - tQoL_AgeDecrements[_stage;\t1])"]
["pMicroalbuminuriaToMacroalbuminuria","0,028 *\tvHR_Intervention_MicroMacro"]
["pMacroalbuminuriaToRenalDisease","0,023 * vHR_Intervention_MacroRenal"]
["pRenalDiseaseToDeath","if(rAge < 64;0,2140;0,3650) * vHR_Intervention_RenalDeath"]
[]
["Formulas above are integrated into cohort analysis sheets in the converted Excel model."]
[]
[]
[]
["Green cells are editable"]
["Gray cells - no impact on calculation"]